The Lamborghini Murciélago LP 640, an evolution of the original Murciélago, was produced between 2006 and 2010 as part of Lamborghini's flagship V12 lineup. Named after a legendary fighting bull, it succeeded the Diablo and was manufactured in Sant'Agata Bolognese, Italy, with approximately 4,099 Murciélago units produced across all variants, though specific LP 640 numbers are lower due to its limited production span. The LP 640 designation reflects its 640 horsepower, derived from an upgraded 6.5-liter V12 engine, a significant boost from the base Murciélago's 6.2-liter unit.

Performance highlights include a top speed of around 211 mph (340 km/h) and a 0-60 mph time of approximately 3.3 seconds, paired with a 6-speed manual or optional E-Gear automated manual transmission. Its all-wheel-drive system and aggressive styling, including scissor doors, make it iconic among exotic car collectors. The LP 640-4 Versace edition, a rare collaboration with the fashion house, adds exclusivity with unique interior and exterior detailing. As a collector's item, the LP 640 holds strong value due to its rarity, final V12 lineage before the Aventador, and historical significance as a product of Lamborghini’s early Audi-era engineering advancements.